Haemorrhagic fever syndrome – South Sudan
Between late December 2015 and early May 2016, the National IHR Focal of South Sudan notified WHO of an outbreak of haemorrhagic fever syndrome.
As of 9 May, a total of 51 suspected cases, including 10 deaths, had been reported from the counties of Aweil North (45 cases, including 10 deaths) and Aweil West (6 cases). No health care workers had been reported among the cases. The majority (74.5%) of the suspected cases are below 20 years of age. The last recorded death dates back to 28 February.
The most frequent symptoms include unexplained bleeding, fever, fatigue, headache and vomiting. The symptoms do not seem to be severe and rapidly resolve following supportive treatment. Currently, there is no evidence of person-to-person transmission of the disease.
Samples of 33 patients were shipped to WHO collaborating centres in Uganda (Uganda Virus Research Institute), Senegal (Institut Pasteur of Dakar) and South Africa (National Institute for Communicable Diseases). The samples were tested by plaque reduction neutralization test, polymerase chain reaction or enzyme-linked immunosorbent assay. All samples were negative for Crimean-Congo haemorrhagic fever, Ebola virus disease, Marburg virus disease, Rift Valley fever, yellow fever, West Nile virus and Zika virus; 5 samples tested positive for Onyong-nyong virus; 3 samples were positive for Chikungunya; and 1 sample tested positive for dengue virus.
Further laboratory testing is ongoing that may confirm the causative agent. Other causes under investigation include bacterial diseases (e.g., Leptospirosis) and food intoxication (mycotoxines). Ecological risk factors for arboviral disease transmission were identified in the affected areas.
The area where the outbreak is occurring borders Darfur in Sudan where at least 469 cases of undiagnosed viral haemorrhagic fever, including 120 deaths, were reported between August and November 2015. Because of frequent population cross-border movement between Sudan and South Sudan, the risk of international spread of the disease cannot be ruled out. WHO continues to monitor the epidemiological situation and conduct risk assessments based on the latest available information.
As of 9 May, a total of 51 suspected cases, including 10 deaths, had been reported from the counties of Aweil North (45 cases, including 10 deaths) and Aweil West (6 cases). No health care workers had been reported among the cases. The majority (74.5%) of the suspected cases are below 20 years of age. The last recorded death dates back to 28 February.
The most frequent symptoms include unexplained bleeding, fever, fatigue, headache and vomiting. The symptoms do not seem to be severe and rapidly resolve following supportive treatment. Currently, there is no evidence of person-to-person transmission of the disease.
Samples of 33 patients were shipped to WHO collaborating centres in Uganda (Uganda Virus Research Institute), Senegal (Institut Pasteur of Dakar) and South Africa (National Institute for Communicable Diseases). The samples were tested by plaque reduction neutralization test, polymerase chain reaction or enzyme-linked immunosorbent assay. All samples were negative for Crimean-Congo haemorrhagic fever, Ebola virus disease, Marburg virus disease, Rift Valley fever, yellow fever, West Nile virus and Zika virus; 5 samples tested positive for Onyong-nyong virus; 3 samples were positive for Chikungunya; and 1 sample tested positive for dengue virus.
Further laboratory testing is ongoing that may confirm the causative agent. Other causes under investigation include bacterial diseases (e.g., Leptospirosis) and food intoxication (mycotoxines). Ecological risk factors for arboviral disease transmission were identified in the affected areas.
Public health response
With support from WHO, national authorities have conducted a number of public health activities, including investigating and managing all newly reported suspected cases, strengthening infection prevention and control as well as improving disease surveillance. Furthermore, community meetings have been conducted to raise people’s awareness of haemorrhagic fever. Finally, in response to a request from the WHO Country Office, laboratory supplies have been mobilized by the WHO Regional Office for Africa.WHO risk assessment
The laboratory results received so far do not explain the symptomatology (unexplained bleeding) of the reported cases nor the high mortality rate. Since the underlying cause of this public health event remains unknown, close monitoring and further epidemiological investigation is needed.The area where the outbreak is occurring borders Darfur in Sudan where at least 469 cases of undiagnosed viral haemorrhagic fever, including 120 deaths, were reported between August and November 2015. Because of frequent population cross-border movement between Sudan and South Sudan, the risk of international spread of the disease cannot be ruled out. WHO continues to monitor the epidemiological situation and conduct risk assessments based on the latest available information.
Lassa Fever – Liberia
Since 1 January 2016, WHO has been notified of at least 38 suspected cases of Lassa fever in Liberia.
Suspected cases were reported from 6 prefectures: Bong (17 cases, including 9 deaths), Nimba (14 cases, including 6 deaths), Gbarpolu (4 cases), Lofa (1 case), Margibi (1 case) and Montserrado (1 case).
Between 1 January and 3 April 2016, samples from 24 suspected cases were received for laboratory testing. Of these 24 suspected cases, 7 are reported to have tested positive for Lassa fever:
Appropriate outbreak response measures, including case management, infection prevention and control, community engagement and health education, have been put in place by the national authorities with the support of WHO and partner organizations.
Although occasional travel-associated cases of Lassa fever have been reported in the past (see DON published on 27 and 8 April 2016), the risk of disease spread from Liberia to non-endemic countries is considered to be low. WHO continues to monitor the epidemiological situation and conduct risk assessments based on the latest available information.
Health-care workers caring for patients with suspected or confirmed Lassa fever should apply extra infection control measures to prevent contact with the patient’s blood and body fluids and contaminated surfaces or materials such as clothing and bedding. When in close contact (within 1 metre) of patients with Lassa fever, health-care workers should wear face protection (a face shield or a medical mask and goggles), a clean, non-sterile long-sleeved gown, and gloves (sterile gloves for some procedures).
Laboratory workers are also at risk. Samples taken from humans and animals for investigation of Lassa virus infection should be handled by trained staff and processed in suitably equipped laboratories under maximum biological containment conditions.
The diagnosis of Lassa fever should be considered in febrile patients returning from areas where Lassa fever is endemic. Health-care workers seeing a patient suspected to have Lassa fever should immediately contact local and national experts for advice and to arrange for laboratory testing.
Suspected cases were reported from 6 prefectures: Bong (17 cases, including 9 deaths), Nimba (14 cases, including 6 deaths), Gbarpolu (4 cases), Lofa (1 case), Margibi (1 case) and Montserrado (1 case).
Between 1 January and 3 April 2016, samples from 24 suspected cases were received for laboratory testing. Of these 24 suspected cases, 7 are reported to have tested positive for Lassa fever:
- 2 cases were identified by polymerase chain reaction (PCR);
- 2 cases were identified through the detection of IgM antibodies using enzyme-linked immunosorbent assay (ELISA);
- 2 cases were identified through the detection of Lassa virus antigens using ELISA;
- information on the type of testing employed to identify the seventh case is not currently available.
Public health response
To date, 134 contacts have completed the 21-day follow-up period. A total of 17 additional contacts are being monitored. None of these contacts have so far developed symptoms.Appropriate outbreak response measures, including case management, infection prevention and control, community engagement and health education, have been put in place by the national authorities with the support of WHO and partner organizations.
WHO risk assessment
Lassa fever is endemic in Liberia and causes outbreaks almost every year in different parts of the country. Based on experiences from previous similar events, it is expected that additional cases will be reported.Although occasional travel-associated cases of Lassa fever have been reported in the past (see DON published on 27 and 8 April 2016), the risk of disease spread from Liberia to non-endemic countries is considered to be low. WHO continues to monitor the epidemiological situation and conduct risk assessments based on the latest available information.
WHO advice
Considering the seasonal flare ups of cases during this time of the year, countries in West Africa that are endemic for Lassa fever are encouraged to strengthen their related surveillance systems.Health-care workers caring for patients with suspected or confirmed Lassa fever should apply extra infection control measures to prevent contact with the patient’s blood and body fluids and contaminated surfaces or materials such as clothing and bedding. When in close contact (within 1 metre) of patients with Lassa fever, health-care workers should wear face protection (a face shield or a medical mask and goggles), a clean, non-sterile long-sleeved gown, and gloves (sterile gloves for some procedures).
Laboratory workers are also at risk. Samples taken from humans and animals for investigation of Lassa virus infection should be handled by trained staff and processed in suitably equipped laboratories under maximum biological containment conditions.
The diagnosis of Lassa fever should be considered in febrile patients returning from areas where Lassa fever is endemic. Health-care workers seeing a patient suspected to have Lassa fever should immediately contact local and national experts for advice and to arrange for laboratory testing.
Middle East respiratory syndrome coronavirus (MERS-CoV) – Saudi Arabia
Between 30 April and 5 May 2016, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East Respiratory Syndrome (MERS-CoV), including one fatal case.
The National IHR Focal Point for the Kingdom of Saudi Arabia also notified WHO of the death of 3 MERS-CoV cases that were reported in previous DONs on 14 April (case no. 1 and 5) and on 22 April (case no. 2).
Globally, since September 2012, WHO has been notified of 1,733 laboratory-confirmed cases of infection with MERS-CoV, including at least 628 related deaths.
The notification of additional cases does not change the overall risk assessment. WHO expects that additional cases of MERS-CoV infection will be reported from the Middle East, and that cases will continue to be exported to other countries by individuals who might acquire the infection after exposure to animals or animal products (for example, following contact with dromedaries) or human source (for example, in a health care setting). WHO continues to monitor the epidemiological situation and conducts risk assessment based on the latest available information.
Infection prevention and control measures are critical to prevent the possible spread of MERS-CoV in health care facilities. It is not always possible to identify patients with MERS-CoV early because like other respiratory infections, the early symptoms of MERS-CoV are non-specific. Therefore, health-care workers should always apply standard precautions consistently with all patients, regardless of their diagnosis. Droplet precautions should be added to the standard precautions when providing care to patients with symptoms of acute respiratory infection; contact precautions and eye protection should be added when caring for probable or confirmed cases of MERS-CoV infection; airborne precautions should be applied when performing aerosol generating procedures.
Until more is understood about MERS-CoV, people with diabetes, renal failure, chronic lung disease, and immunocompromised persons are considered to be at high risk of severe disease from MERS‐CoV infection. Therefore, these people should avoid close contact with animals, particularly camels, when visiting farms, markets, or barn areas where the virus is known to be potentially circulating. General hygiene measures, such as regular hand washing before and after touching animals and avoiding contact with sick animals, should be adhered to.
Food hygiene practices should be observed. People should avoid drinking raw camel milk or camel urine, or eating meat that has not been properly cooked.
Given the lack of evidence of sustained human-to-human transmission in the community, WHO does not recommend travel or trade restrictions with regard to this event. Raising awareness about MERS-CoV among travellers to and from affected countries is good public health practice.
Details of the cases
- A 39-year-old, non-national, male living in Riyadh city is a household contact of another MERS-CoV (see case no. 2 below). He is asymptomatic and identified through tracing of contacts. The patient, who has no comorbid conditions, tested positive for MERS-CoV on 5 May. The patient is currently in home isolation.
- A 40-year-old, non-national, male living in Riyadh city developed symptoms on 14 April and was admitted to hospital on 1 May. On 2 May, the patient, who has comorbidities, tested positive for MERS-CoV. Investigation of history of exposure to the known risk factors in the 14 days prior to symptom onset is ongoing. Currently the patient is in critical condition admitted to ICU, but not on mechanical ventilation.
- A 55-year-old, national male living in Hofuf city developed symptoms on 26 April and was admitted to hospital on 29 April. The patient, who had comorbidities, tested positive for MERS-CoV on 30 April. He passed away on 4 May. He had history of frequent contact with dromedaries and consumption of their raw milk. The Ministry of Agriculture was notified and investigation of dromedaries is ongoing.
- A 70-year-old, national, male living in Hail city developed symptoms on 26 April and was admitted to hospital on 28 April. The patient, who has comorbidities, tested positive for MERS-CoV on 30 April. Investigation of history of exposure to the known risk factors in the 14 days prior to symptom onset is ongoing. Currently the patient is in critical condition admitted to ICU on mechanical ventilation.
The National IHR Focal Point for the Kingdom of Saudi Arabia also notified WHO of the death of 3 MERS-CoV cases that were reported in previous DONs on 14 April (case no. 1 and 5) and on 22 April (case no. 2).
Globally, since September 2012, WHO has been notified of 1,733 laboratory-confirmed cases of infection with MERS-CoV, including at least 628 related deaths.
WHO risk assessment
MERS-CoV causes severe human infections resulting in high mortality and has demonstrated the ability to transmit between humans. So far, the observed human-to-human transmission has occurred mainly in health care settings.The notification of additional cases does not change the overall risk assessment. WHO expects that additional cases of MERS-CoV infection will be reported from the Middle East, and that cases will continue to be exported to other countries by individuals who might acquire the infection after exposure to animals or animal products (for example, following contact with dromedaries) or human source (for example, in a health care setting). WHO continues to monitor the epidemiological situation and conducts risk assessment based on the latest available information.
WHO advice
Based on the current situation and available information, WHO encourages all Member States to continue their surveillance for acute respiratory infections and to carefully review any unusual patterns.Infection prevention and control measures are critical to prevent the possible spread of MERS-CoV in health care facilities. It is not always possible to identify patients with MERS-CoV early because like other respiratory infections, the early symptoms of MERS-CoV are non-specific. Therefore, health-care workers should always apply standard precautions consistently with all patients, regardless of their diagnosis. Droplet precautions should be added to the standard precautions when providing care to patients with symptoms of acute respiratory infection; contact precautions and eye protection should be added when caring for probable or confirmed cases of MERS-CoV infection; airborne precautions should be applied when performing aerosol generating procedures.
Until more is understood about MERS-CoV, people with diabetes, renal failure, chronic lung disease, and immunocompromised persons are considered to be at high risk of severe disease from MERS‐CoV infection. Therefore, these people should avoid close contact with animals, particularly camels, when visiting farms, markets, or barn areas where the virus is known to be potentially circulating. General hygiene measures, such as regular hand washing before and after touching animals and avoiding contact with sick animals, should be adhered to.
Food hygiene practices should be observed. People should avoid drinking raw camel milk or camel urine, or eating meat that has not been properly cooked.
Given the lack of evidence of sustained human-to-human transmission in the community, WHO does not recommend travel or trade restrictions with regard to this event. Raising awareness about MERS-CoV among travellers to and from affected countries is good public health practice.
Middle East respiratory syndrome coronavirus (MERS-CoV) – Qatar
On 4 May 2016, the National IHR Focal Point of Qatar notified WHO of one additional case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection.
The Department of Health Protection and Communicable Disease Control in the Ministry of Public Health has immediately carried out case investigation and contact tracing activities. Samples were collected from household contacts and health care workers. All tested negative for MERS-CoV.
Contacts will be followed up until the end of the 14-day monitoring period following the last exposure to the case. Health education messages about appropriate preventive measures were shared with all contacts and they were advised to comply with the recommended preventive measure against MERS-CoV infection, and to report to the health authorities on the development of any respiratory symptoms. Infection prevention and control measures in all health facilities have been reinforced by the Ministry of Public Health.
The Ministry of Agriculture and Animal Resources has been notified and investigation of the dromedaries is ongoing.
Globally, since September 2012, WHO has been notified of 1,729 laboratory-confirmed cases of infection with MERS-CoV, including at least 624 related deaths.
The notification of additional cases does not change the overall risk assessment. WHO expects that additional cases of MERS-CoV infection will be reported from the Middle East, and that cases will continue to be exported to other countries by individuals who might acquire the infection after exposure to animals or animal products (for example, following contact with dromedaries) or human source (for example, in a health care setting). WHO continues to monitor the epidemiological situation and conducts risk assessment based on the latest available information.
Infection prevention and control measures are critical to prevent the possible spread of MERS-CoV in health care facilities. It is not always possible to identify patients with MERS-CoV early because like other respiratory infections, the early symptoms of MERS-CoV are non-specific. Therefore, health-care workers should always apply standard precautions consistently with all patients, regardless of their diagnosis. Droplet precautions should be added to the standard precautions when providing care to patients with symptoms of acute respiratory infection; contact precautions and eye protection should be added when caring for probable or confirmed cases of MERS-CoV infection; airborne precautions should be applied when performing aerosol generating procedures.
Until more is understood about MERS-CoV, people with diabetes, renal failure, chronic lung disease, and immunocompromised persons are considered to be at high risk of severe disease from MERS‐CoV infection. Therefore, these people should avoid close contact with animals, particularly camels, when visiting farms, markets, or barn areas where the virus is known to be potentially circulating. General hygiene measures, such as regular hand washing before and after touching animals and avoiding contact with sick animals, should be adhered to.
Food hygiene practices should be observed. People should avoid drinking raw camel milk or camel urine, or eating meat that has not been properly cooked.
Given the lack of evidence of sustained human-to-human transmission in the community, WHO does not recommend travel or trade restrictions with regard to this event. Raising awareness about MERS-CoV among travellers to and from affected countries is good public health practice.
Details of the case
A 40-year-old, male, Qatari national was admitted to hospital on 26 April for an unrelated medical condition. On 1 May, the patient reported having frequent exposure to dromedaries as part of his work. He tested positive for MERS-CoV on 2 May and 3 May. The patient has no other comorbid conditions and no history of exposure to the other known risk factors in the 14 days prior to onset of symptoms. He is currently in stable condition, admitted to a negative pressure isolation room.The Department of Health Protection and Communicable Disease Control in the Ministry of Public Health has immediately carried out case investigation and contact tracing activities. Samples were collected from household contacts and health care workers. All tested negative for MERS-CoV.
Contacts will be followed up until the end of the 14-day monitoring period following the last exposure to the case. Health education messages about appropriate preventive measures were shared with all contacts and they were advised to comply with the recommended preventive measure against MERS-CoV infection, and to report to the health authorities on the development of any respiratory symptoms. Infection prevention and control measures in all health facilities have been reinforced by the Ministry of Public Health.
The Ministry of Agriculture and Animal Resources has been notified and investigation of the dromedaries is ongoing.
Globally, since September 2012, WHO has been notified of 1,729 laboratory-confirmed cases of infection with MERS-CoV, including at least 624 related deaths.
WHO risk assessment
MERS-CoV causes severe human infections resulting in high mortality and has demonstrated the ability to transmit between humans. So far, the observed human-to-human transmission has occurred mainly in health care settings.The notification of additional cases does not change the overall risk assessment. WHO expects that additional cases of MERS-CoV infection will be reported from the Middle East, and that cases will continue to be exported to other countries by individuals who might acquire the infection after exposure to animals or animal products (for example, following contact with dromedaries) or human source (for example, in a health care setting). WHO continues to monitor the epidemiological situation and conducts risk assessment based on the latest available information.
WHO advice
Based on the current situation and available information, WHO encourages all Member States to continue their surveillance for acute respiratory infections and to carefully review any unusual patterns.Infection prevention and control measures are critical to prevent the possible spread of MERS-CoV in health care facilities. It is not always possible to identify patients with MERS-CoV early because like other respiratory infections, the early symptoms of MERS-CoV are non-specific. Therefore, health-care workers should always apply standard precautions consistently with all patients, regardless of their diagnosis. Droplet precautions should be added to the standard precautions when providing care to patients with symptoms of acute respiratory infection; contact precautions and eye protection should be added when caring for probable or confirmed cases of MERS-CoV infection; airborne precautions should be applied when performing aerosol generating procedures.
Until more is understood about MERS-CoV, people with diabetes, renal failure, chronic lung disease, and immunocompromised persons are considered to be at high risk of severe disease from MERS‐CoV infection. Therefore, these people should avoid close contact with animals, particularly camels, when visiting farms, markets, or barn areas where the virus is known to be potentially circulating. General hygiene measures, such as regular hand washing before and after touching animals and avoiding contact with sick animals, should be adhered to.
Food hygiene practices should be observed. People should avoid drinking raw camel milk or camel urine, or eating meat that has not been properly cooked.
Given the lack of evidence of sustained human-to-human transmission in the community, WHO does not recommend travel or trade restrictions with regard to this event. Raising awareness about MERS-CoV among travellers to and from affected countries is good public health practice.
Nutritional Deficiencies
Nutritional deficiencies, known as malnutrition, are the result of your body not getting enough of the nutrients it needs.
The body requires a wide range of vitamins and minerals that are pivotal for both advancement and counteracting sickness. These vitamins and minerals are frequently alluded to as micronutrients. They aren't delivered actually in the body, so you need to get them from your eating routine.
A healthful inadequacy happens when the body doesn't ingest the fundamental measure of a supplement. Lacks can prompt an assortment of wellbeing issues. These can incorporate issues of assimilation, skin issues, hindered or damaged bone development, and even dementia.
The measure of every supplement you ought to devour relies on upon your age. In the United States, numerous sustenances that you purchase in the market, (for example, oats, bread, and drain) are braced with supplements that are important to forestall wholesome lack. Be that as it may, now and again your body can't retain certain supplements regardless of the possibility that you are expending them.
It's conceivable to be lacking in any of the supplements that your body needs. Some basic sorts of wholesome lacks include:
Iron Deficiency
The most across the board nourishing insufficiency worldwide is iron inadequacy. Iron inadequacy can prompt frailty, a blood issue that causes weariness, shortcoming, and an assortment of different manifestations.
Iron is found in nourishments, for example, dim verdant greens, red meat, and egg yolks. It helps your body make red platelets. When you're iron insufficient, your body produces less red platelets. The red platelets it produces are littler and paler than solid platelets. They're additionally less effective at conveying oxygen to your tissues and organs.
As indicated by the World Health Organization (WHO), more than 30 percent of the world's populace experiences this condition. Indeed, it's the main healthful insufficiency that is pervasive in both creating and industrialized nations. Iron-insufficiency weakness influences such a variety of individuals that it's currently broadly perceived as a general wellbeing pandemic.
Vitamin A Deficiency
Vitamin A will be a gathering of supplements that is critical for eye wellbeing and working and conceptive wellbeing in men and ladies. It likewise has influence in reinforcing the safe framework against diseases. As per the WHO, an absence of vitamin An is the main source of preventable visual impairment in youngsters. Pregnant ladies who are lacking in vitamin A have higher maternal death rates too.
For infants, the best wellspring of vitamin An is bosom milk. For others, it's essential to eat a lot of sustenances that are high in vitamin A. These include:
milk
eggs
green vegetables, for example, kale, broccoli, and spinach
orange vegetables like carrots, sweet potatoes, and pumpkin
rosy yellow natural products, similar to apricots, papaya, and peaches
Vitamin B-1 (Thiamine) Deficiency
Another regular nutritious lack happens with vitamin B-1, otherwise called thiamine. Thiamine is a vital piece of your sensory system. It likewise helps your body transform sugars into vitality as a feature of your digestion system.
An absence of thiamine can bring about weight reduction and weariness, and also some psychological indications, for example, disarray and transient memory misfortune. Thiamine insufficiency can likewise prompt nerve and muscle harm and can influence the heart. In the United States, thiamine insufficiency is frequently found in the individuals who incessantly manhandle liquor. Liquor lessens the retention of thiamine, the body's capacity to store thiamine in the liver and the body's capacity to change over thiamine to a usable structure. Thiamine insufficiency is a typical reason for Wernicke-Korsakoff disorder.
Numerous breakfast oats and grain items in the United States are sustained with thiamine. Pork is additionally a decent wellspring of the vitamin.
Vitamin B-3 (Niacin) Deficiency
Vitamin B-3 (niacin) is another mineral that helps the body change over sustenance into vitality. A serious inadequacy of niacin is frequently alluded to as pellagra. Niacin is found in many proteins. Accordingly, this condition is uncommon in meat eating groups. Indications of pellagra incorporate loose bowels, dementia, and skin issues. You can normally treat it with an adjusted eating regimen and vitamin B-3 supplements.
Vitamin B-9 (Folate) Deficiency
Vitamin B-9, regularly alluded to as folate (folic corrosive is the engineered structure found in supplements or sustained nourishments), helps the body make red platelets and produce DNA. It additionally brains improvement and sensory system working.
Folate is particularly essential for fetal advancement. It assumes a significant part in the arrangement of a building up kid's cerebrum and spinal rope. Folate inadequacy can prompt extreme birth deformities, development issues, or frailty.
You can discover folate in nourishments, including:
beans and lentils
citrus natural products
verdant green vegetables
asparagus
meats, for example, poultry and pork
shellfish
strengthened grain items
The vast majority in the United States get enough folate. Be that as it may, pregnant ladies and ladies of childbearing age once in a while don't expend enough folate for a solid pregnancy. The National Institutes of Health (NIH) prescribe that ladies who are pregnant or who may get to be pregnant expend up to 400 mg of folate or folic corrosive every day to anticipate birth imperfections.
Vitamin D Deficiency
As indicated by the Vitamin D Council, around 40 percent of the populace worldwide is influenced by vitamin D lack. Dull cleaned people are at a higher danger of vitamin D inadequacy.
Vitamin D is key for sound bones. It helps the body keep up the right levels of calcium with a specific end goal to control the improvement of teeth and bones. An absence of this supplement can prompt hindered or flawed bone development. Osteoporosis, created by an absence of calcium and vitamin D, can prompt permeable and delicate bones that break effectively.
Vitamin D is discovered normally in just a couple of sustenances. Nourishments with vitamin D include:
fish liver oils
greasy fish
mushrooms
egg yolks
liver
Numerous dairy items in the United States are sustained with vitamin D. Bright light from the sun is likewise a wellspring of vitamin D. As per the NIH's Office of Dietary Supplements, research proposes that five to 30 minutes of sun presentation twice per week on the face, arms, neck, or back can give you enough vitamin D. (Despite the fact that prescribed for UV insurance, sunscreen hinders vitamin D ingestion from daylight through the skin, so spend a couple of minutes in the sun before sunscreen for ideal vitamin D retention).
Calcium Deficiency
Calcium helps your body create solid bones and teeth. It additionally helps your heart, nerves, and muscles work they way they ought to. A calcium inadequacy regularly doesn't indicate side effects immediately, however it can prompt genuine wellbeing issues after some time. On the off chance that you aren't sufficiently devouring calcium, your body will utilize the calcium from your bones rather, prompting bone misfortune.
Calcium lacks are identified with low bone mass, debilitating of bones because of osteoporosis, writhings, and anomalous heart rhythms. They can even be life-undermining. Postmenopausal ladies experience more noteworthy bone misfortune because of changing hormones and experience more difficulty engrossing calcium.
The best wellsprings of calcium are dairy items, for example, milk, yogurt, cheddar, calcium-set tofu, and little fish with bones. Vegetables like kale and broccoli additionally have calcium, and numerous oats and grains are calcium-invigorated.
The typical reason for nutritious insufficiencies is a terrible eating routine that needs vital supplements. The body stores supplements, so an inadequacy is normally gotten after it's been without the supplement for quite a while.
Various infections and conditions — including colon malignancy and gastrointestinal conditions — can prompt an iron lack. Pregnancy can likewise bring about an insufficiency if the body occupies iron to the baby.
Analysts have discovered relationship between bariatric (surgery that diminishes the extent of the stomach to accomplish weight reduction) and dietary insufficiency. Individuals who are possibility for bariatric surgery may as of now be supplement insufficient because of horrible eating routine. Prior and then afterward the surgery, you ought to converse with your specialist and dietitian to set up a careful sustenance arrangement.
The manifestations of a dietary insufficiency rely on upon which supplement the body needs. In any case, there are some broad manifestations you may encounter, including:
paleness (fair skin)
weakness
shortcoming
inconvenience relaxing
bizarre sustenance longings
male pattern baldness
times of tipsiness
obstruction
sluggishness
heart palpitations
feeling black out or swooning
melancholy
shivering and deadness of the joints
menstrual issues, (for example, missed periods or substantial cycles)
poor focus
You may show these side effects or just gatherings of them. After some time, a great many people adjust to the manifestations. This can bring about the condition to go undiscovered. Plan a checkup with your specialist on the off chance that you encounter delayed times of exhaustion, shortcoming, or poor focus. These indications could be an indication of the start of a genuine insufficiency.
Your specialist will talk about your eating routine and dietary patterns with you on the off chance that they think you have a wholesome inadequacy. They will ask what manifestations you're encountering. Try to say in the event that you have experienced any times of clogging or looseness of the bowels, or if blood has been available in your stool.
Your nourishing inadequacy may likewise be analyzed amid routine blood tests, including a complete blood tally (CBC). This is regularly how specialists recognize iron deficiency.
The treatment for a wholesome insufficiency relies on upon the sort and the seriousness of the inadequacy. Your specialist will discover how extreme the insufficiency is, and additionally the probability of long haul issues brought on by the absence of supplements. They may arrange further testing to check whether there is some other harm before settling on a treatment arrangement. Side effects more often than not blur when the right eating regimen is taken after or supplemented.
Dietary Changes
A specialist may prompt you on the most proficient method to change your ea
A healthful inadequacy happens when the body doesn't ingest the fundamental measure of a supplement. Lacks can prompt an assortment of wellbeing issues. These can incorporate issues of assimilation, skin issues, hindered or damaged bone development, and even dementia.
The measure of every supplement you ought to devour relies on upon your age. In the United States, numerous sustenances that you purchase in the market, (for example, oats, bread, and drain) are braced with supplements that are important to forestall wholesome lack. Be that as it may, now and again your body can't retain certain supplements regardless of the possibility that you are expending them.
It's conceivable to be lacking in any of the supplements that your body needs. Some basic sorts of wholesome lacks include:
Iron Deficiency
The most across the board nourishing insufficiency worldwide is iron inadequacy. Iron inadequacy can prompt frailty, a blood issue that causes weariness, shortcoming, and an assortment of different manifestations.
Iron is found in nourishments, for example, dim verdant greens, red meat, and egg yolks. It helps your body make red platelets. When you're iron insufficient, your body produces less red platelets. The red platelets it produces are littler and paler than solid platelets. They're additionally less effective at conveying oxygen to your tissues and organs.
As indicated by the World Health Organization (WHO), more than 30 percent of the world's populace experiences this condition. Indeed, it's the main healthful insufficiency that is pervasive in both creating and industrialized nations. Iron-insufficiency weakness influences such a variety of individuals that it's currently broadly perceived as a general wellbeing pandemic.
Vitamin A Deficiency
Vitamin A will be a gathering of supplements that is critical for eye wellbeing and working and conceptive wellbeing in men and ladies. It likewise has influence in reinforcing the safe framework against diseases. As per the WHO, an absence of vitamin An is the main source of preventable visual impairment in youngsters. Pregnant ladies who are lacking in vitamin A have higher maternal death rates too.
For infants, the best wellspring of vitamin An is bosom milk. For others, it's essential to eat a lot of sustenances that are high in vitamin A. These include:
milk
eggs
green vegetables, for example, kale, broccoli, and spinach
orange vegetables like carrots, sweet potatoes, and pumpkin
rosy yellow natural products, similar to apricots, papaya, and peaches
Vitamin B-1 (Thiamine) Deficiency
Another regular nutritious lack happens with vitamin B-1, otherwise called thiamine. Thiamine is a vital piece of your sensory system. It likewise helps your body transform sugars into vitality as a feature of your digestion system.
An absence of thiamine can bring about weight reduction and weariness, and also some psychological indications, for example, disarray and transient memory misfortune. Thiamine insufficiency can likewise prompt nerve and muscle harm and can influence the heart. In the United States, thiamine insufficiency is frequently found in the individuals who incessantly manhandle liquor. Liquor lessens the retention of thiamine, the body's capacity to store thiamine in the liver and the body's capacity to change over thiamine to a usable structure. Thiamine insufficiency is a typical reason for Wernicke-Korsakoff disorder.
Numerous breakfast oats and grain items in the United States are sustained with thiamine. Pork is additionally a decent wellspring of the vitamin.
Vitamin B-3 (Niacin) Deficiency
Vitamin B-3 (niacin) is another mineral that helps the body change over sustenance into vitality. A serious inadequacy of niacin is frequently alluded to as pellagra. Niacin is found in many proteins. Accordingly, this condition is uncommon in meat eating groups. Indications of pellagra incorporate loose bowels, dementia, and skin issues. You can normally treat it with an adjusted eating regimen and vitamin B-3 supplements.
Vitamin B-9 (Folate) Deficiency
Vitamin B-9, regularly alluded to as folate (folic corrosive is the engineered structure found in supplements or sustained nourishments), helps the body make red platelets and produce DNA. It additionally brains improvement and sensory system working.
Folate is particularly essential for fetal advancement. It assumes a significant part in the arrangement of a building up kid's cerebrum and spinal rope. Folate inadequacy can prompt extreme birth deformities, development issues, or frailty.
You can discover folate in nourishments, including:
beans and lentils
citrus natural products
verdant green vegetables
asparagus
meats, for example, poultry and pork
shellfish
strengthened grain items
The vast majority in the United States get enough folate. Be that as it may, pregnant ladies and ladies of childbearing age once in a while don't expend enough folate for a solid pregnancy. The National Institutes of Health (NIH) prescribe that ladies who are pregnant or who may get to be pregnant expend up to 400 mg of folate or folic corrosive every day to anticipate birth imperfections.
Vitamin D Deficiency
As indicated by the Vitamin D Council, around 40 percent of the populace worldwide is influenced by vitamin D lack. Dull cleaned people are at a higher danger of vitamin D inadequacy.
Vitamin D is key for sound bones. It helps the body keep up the right levels of calcium with a specific end goal to control the improvement of teeth and bones. An absence of this supplement can prompt hindered or flawed bone development. Osteoporosis, created by an absence of calcium and vitamin D, can prompt permeable and delicate bones that break effectively.
Vitamin D is discovered normally in just a couple of sustenances. Nourishments with vitamin D include:
fish liver oils
greasy fish
mushrooms
egg yolks
liver
Numerous dairy items in the United States are sustained with vitamin D. Bright light from the sun is likewise a wellspring of vitamin D. As per the NIH's Office of Dietary Supplements, research proposes that five to 30 minutes of sun presentation twice per week on the face, arms, neck, or back can give you enough vitamin D. (Despite the fact that prescribed for UV insurance, sunscreen hinders vitamin D ingestion from daylight through the skin, so spend a couple of minutes in the sun before sunscreen for ideal vitamin D retention).
Calcium Deficiency
Calcium helps your body create solid bones and teeth. It additionally helps your heart, nerves, and muscles work they way they ought to. A calcium inadequacy regularly doesn't indicate side effects immediately, however it can prompt genuine wellbeing issues after some time. On the off chance that you aren't sufficiently devouring calcium, your body will utilize the calcium from your bones rather, prompting bone misfortune.
Calcium lacks are identified with low bone mass, debilitating of bones because of osteoporosis, writhings, and anomalous heart rhythms. They can even be life-undermining. Postmenopausal ladies experience more noteworthy bone misfortune because of changing hormones and experience more difficulty engrossing calcium.
The best wellsprings of calcium are dairy items, for example, milk, yogurt, cheddar, calcium-set tofu, and little fish with bones. Vegetables like kale and broccoli additionally have calcium, and numerous oats and grains are calcium-invigorated.
The typical reason for nutritious insufficiencies is a terrible eating routine that needs vital supplements. The body stores supplements, so an inadequacy is normally gotten after it's been without the supplement for quite a while.
Various infections and conditions — including colon malignancy and gastrointestinal conditions — can prompt an iron lack. Pregnancy can likewise bring about an insufficiency if the body occupies iron to the baby.
Analysts have discovered relationship between bariatric (surgery that diminishes the extent of the stomach to accomplish weight reduction) and dietary insufficiency. Individuals who are possibility for bariatric surgery may as of now be supplement insufficient because of horrible eating routine. Prior and then afterward the surgery, you ought to converse with your specialist and dietitian to set up a careful sustenance arrangement.
The manifestations of a dietary insufficiency rely on upon which supplement the body needs. In any case, there are some broad manifestations you may encounter, including:
paleness (fair skin)
weakness
shortcoming
inconvenience relaxing
bizarre sustenance longings
male pattern baldness
times of tipsiness
obstruction
sluggishness
heart palpitations
feeling black out or swooning
melancholy
shivering and deadness of the joints
menstrual issues, (for example, missed periods or substantial cycles)
poor focus
You may show these side effects or just gatherings of them. After some time, a great many people adjust to the manifestations. This can bring about the condition to go undiscovered. Plan a checkup with your specialist on the off chance that you encounter delayed times of exhaustion, shortcoming, or poor focus. These indications could be an indication of the start of a genuine insufficiency.
Your specialist will talk about your eating routine and dietary patterns with you on the off chance that they think you have a wholesome inadequacy. They will ask what manifestations you're encountering. Try to say in the event that you have experienced any times of clogging or looseness of the bowels, or if blood has been available in your stool.
Your nourishing inadequacy may likewise be analyzed amid routine blood tests, including a complete blood tally (CBC). This is regularly how specialists recognize iron deficiency.
The treatment for a wholesome insufficiency relies on upon the sort and the seriousness of the inadequacy. Your specialist will discover how extreme the insufficiency is, and additionally the probability of long haul issues brought on by the absence of supplements. They may arrange further testing to check whether there is some other harm before settling on a treatment arrangement. Side effects more often than not blur when the right eating regimen is taken after or supplemented.
Dietary Changes
A specialist may prompt you on the most proficient method to change your ea
Human infection with avian influenza A(H5N6) virus China– 10 May 2016
On 4 May 2016, the National Health and Family Planning Commission (NHFPC) of China notified WHO of an additional laboratory-confirmed case of human infection with avian influenza A(H5N6) virus.
Details of the case
- A 65-year-old female living in Xuancheng City, Anhui province developed symptoms on 24 April. On 27 April, her condition worsened and she was admitted to a local hospital for treatment and is currently in critical condition. The patient’s clinical sample was confirmed to be A(H5N6) virus nucleic acid positive by the Chinese Center for Disease Control and Prevention (China CDC) on 2 May. She had exposure to live poultry before symptom onset. This is the first A(H5N6) case reported from Anhui province, China.
Public health response
The Chinese Government has taken the following surveillance and control measures:- strengthening surveillance, analysis and research;
- further enhancing the medical care of the case;
- conducting public risk communication and releasing information.
WHO risk assessment
This report does not change the overall public health risk associated with avian influenza A(H5N6) viruses. Although influenza A(H5N6) has caused severe infection in humans, until now human infections with the virus seem to be sporadic with no ongoing human to human transmission and close contacts of the case remain healthy. However, the characterization of this virus is ongoing and its implication to the evolution and emergence of a pandemic strain is unknown. The risk of international disease spread is considered to be low at this point in time. WHO continues to assess the epidemiological situation and conduct further risk assessment based on the latest information.WHO advice
WHO advises that travellers to countries with known outbreaks of avian influenza should avoid poultry farms, contact with animals in live bird markets, entering areas where poultry may be slaughtered, or contact with any surfaces that appear to be contaminated with faeces from poultry or other animals. Travellers should also wash their hands often with soap and water. Travellers should follow good food safety and good food hygiene practices.WHO does not advise special screening at points of entry with regard to this event, nor does it currently recommend any travel or trade restrictions. As always, a diagnosis of infection with an avian influenza virus should be considered in individuals who develop severe acute respiratory symptoms while travelling or soon after returning from an area where avian influenza is a concern.
WHO encourages countries to continue strengthening influenza surveillance, including surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns, in order to ensure reporting of human infections under the IHR (2005), and continue national health preparedness actions.
Human infection with avian influenza A(H5N6) virus – China
Between 21 and 26 April 2016, the National Health and Family Planning Commission (NHFPC) of China notified WHO of 2 additional laboratory-confirmed cases of human infection with avian influenza A(H5N6) virus.
Details of the cases
- A 35-year-old male living in Shen Nong Jia forest region, Hubei Province developed fever on 9 April and sought medical care. He was admitted to hospital for treatment on 12 April and is currently in critical condition. The patient’s clinical sample was confirmed to be A(H5N6) virus nucleic acid positive by the Chinese Center for Disease Control and Prevention (China CDC) on 21 April. He had exposure to a live poultry market before symptom onset. Close contacts of the patient remain healthy.
- An 11-year-old female living in Zhuzhou City, Hunan Province developed fever and cough on 11 April. As her symptoms worsened on 12 April, the patient was admitted to hospital for treatment. She is currently in stable condition. The patient’s clinical sample was confirmed to be A(H5N6) virus nucleic acid positive by the Chinese Center for Disease Control and Prevention (China CDC) on 24 April. She was exposed to live poultry before onset of the disease. Close contacts of the patient remain healthy.
Public health response
The Chinese Government has taken the following surveillance and control measures:- strengthening surveillance, analysis and research;
- further enhancing the medical care of the case;
- conducting public risk communication and releasing information.
WHO risk assessment
This report does not change the overall public health risk from avian influenza A(H5N6) viruses. Although influenza A(H5N6) has caused severe infection in humans, until now human infections with the virus seem to be sporadic with no ongoing human to human transmission and close contacts of the case remain healthy. However, the characterization of this virus is ongoing and its implication to the evolution and emergence of a pandemic strain is unknown. The risk of international disease spread is considered to be low at this point in time. WHO continues to assess the epidemiological situation and conduct further risk assessment based on the latest information.WHO advice
WHO advises that travellers to countries with known outbreaks of avian influenza should avoid poultry farms, contact with animals in live bird markets, entering areas where poultry may be slaughtered, or contact with any surfaces that appear to be contaminated with faeces from poultry or other animals. Travellers should also wash their hands often with soap and water. Travellers should follow good food safety and good food hygiene practices.Human infection with avian influenza A(H7N9) virus – China
On 18 April 2016, the National Health and Family Planning Commission (NHFPC) of China notified WHO of 17 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus, including 5 deaths.
Onset dates range from 21 February to 20 March. Cases range in age from 26 to 86 years, with a median age of 60 years. Of these 17 cases, 11 (65%) are male. The majority (15 cases, 88%) reported exposure to live poultry, slaughtered poultry, or live poultry markets. The exposure history of one (1) case is unknown. One (1) case is linked to a cluster of two (2) cases reported earlier to WHO (see below).
Cases were reported from 6 provinces and municipalities: Anhui (4), Jiangsu (4), Fujian (3), Guangdong (3), Zhejiang (2) and Hubei (1).
One cluster was reported. The cluster includes an 85-year-old female from Zhejiang Province. She had onset of symptoms on 1 March and passed away on 8 March. She had been admitted to the same hospital and shared the ward with a confirmed case between 22 and 23 February. She was not exposed to live poultry or live poultry market, according to her relatives.
The confirmed case admitted at the same ward was a 29-year-old male from Zhejiang Province who developed symptoms on 15 February. He had exposure to a live poultry market and a household contact who was also a confirmed case. The contact from Fujian Province developed symptoms on 4 February and had exposure to a live poultry market.
Human to human transmission between the 29-year-old male and the 85-year-old female cannot be ruled out. Further virological information is awaited.
Human infections with the A(H7N9) virus are unusual and need to be monitored closely in order to identify changes in the virus and/or its transmission behaviour to humans as it may have a serious public health impact.
Onset dates range from 21 February to 20 March. Cases range in age from 26 to 86 years, with a median age of 60 years. Of these 17 cases, 11 (65%) are male. The majority (15 cases, 88%) reported exposure to live poultry, slaughtered poultry, or live poultry markets. The exposure history of one (1) case is unknown. One (1) case is linked to a cluster of two (2) cases reported earlier to WHO (see below).
Cases were reported from 6 provinces and municipalities: Anhui (4), Jiangsu (4), Fujian (3), Guangdong (3), Zhejiang (2) and Hubei (1).
One cluster was reported. The cluster includes an 85-year-old female from Zhejiang Province. She had onset of symptoms on 1 March and passed away on 8 March. She had been admitted to the same hospital and shared the ward with a confirmed case between 22 and 23 February. She was not exposed to live poultry or live poultry market, according to her relatives.
The confirmed case admitted at the same ward was a 29-year-old male from Zhejiang Province who developed symptoms on 15 February. He had exposure to a live poultry market and a household contact who was also a confirmed case. The contact from Fujian Province developed symptoms on 4 February and had exposure to a live poultry market.
Human to human transmission between the 29-year-old male and the 85-year-old female cannot be ruled out. Further virological information is awaited.
Public health response
The Chinese Government has taken the following surveillance and control measures:- strengthening outbreak surveillance and situation analysis;
- reinforcing all efforts on medical treatment; and
- conducting risk communication with the public and dissemination of information.
WHO risk assessment
Most human cases are exposed to the A(H7N9) virus through contact with infected poultry or contaminated environments, including live poultry markets. Since the virus continues to be detected in animals and environments, further human cases can be expected. Although small clusters of human cases with influenza A(H7N9) viruses have been reported including those involving healthcare workers, current epidemiological and virological evidence suggests that this virus has not acquired the ability of sustained transmission among humans. Therefore further community level spread is considered unlikely.Human infections with the A(H7N9) virus are unusual and need to be monitored closely in order to identify changes in the virus and/or its transmission behaviour to humans as it may have a serious public health impact.
WHO advice
WHO advises that travellers to countries with known outbreaks of avian influenza should avoid poultry farms, contact with animals in live bird markets, entering areas where poultry may be slaughtered, or contact with any surfaces that appear to be contaminated with faeces from poultry or other animals. Travellers should also wash their hands often with soap and water. Travellers should follow good food safety and good food hygiene practices.Yellow fever – Uganda 2 May 2016
On 8 April 2016, the National IHR Focal Point of Uganda notified WHO of an outbreak of Yellow Fever (YF) in Masaka district, south of Kampala.
An alert concerning a suspected outbreak of viral haemorrhagic fever in Kaloddo village, Masaka district was initially sent on 26 March. A cluster of three cases from a single family was reported after patients presented with high-grade fever, were non-responsive to anti-malarial treatment with haemorrhaging signs and acute neurological signs (convulsions and unconsciousness).
From 28 March to 1 April, a rapid response team (RRT) was deployed to carry out investigation and response activities. The RRT confirmed the deaths, activated the district task force, set up a treatment facility in Masaka, and collected and referred samples to the Uganda Virus Research Institute (UVRI) for laboratory testing. In addition, the team used a case definition for haemorrhagic fevers and proceeded to carry out active case search to identify additional suspected cases.
On 29 and 30 March, 6 samples were sent to the UVRI and tested negative for all Ebola virus disease, Marburg virus disease, Crimean-Congo haemorrhagic fever, Rift Valley fever by polymerase chain reaction (PCR). On 8 April, Yellow Fever was confirmed on three samples by PCR, two blood samples tested positive for salmonella non-typhi and one tested positive for malaria. On 21 April, at least four samples were re-confirmed positive by PCR at CDC Fort Collins (WHO Collaborative Center for Yellow Fever).
From 26 March to 18 April, 30 cumulative suspected cases, including 7 deaths, were reported from Masaka, Rukungiri, Ntungamo, Bukumansimbi, Kalungu, Lyantonde, and Rakai. Of these, 6 cases and 2 deaths were confirmed in Masaka district (5 cases), and Rukungiri district (1 case). The mean age of the cases is 23 years old. The majority of cases are male. The cases do not have any history of travel outside of Uganda.
An alert concerning a suspected outbreak of viral haemorrhagic fever in Kaloddo village, Masaka district was initially sent on 26 March. A cluster of three cases from a single family was reported after patients presented with high-grade fever, were non-responsive to anti-malarial treatment with haemorrhaging signs and acute neurological signs (convulsions and unconsciousness).
From 28 March to 1 April, a rapid response team (RRT) was deployed to carry out investigation and response activities. The RRT confirmed the deaths, activated the district task force, set up a treatment facility in Masaka, and collected and referred samples to the Uganda Virus Research Institute (UVRI) for laboratory testing. In addition, the team used a case definition for haemorrhagic fevers and proceeded to carry out active case search to identify additional suspected cases.
On 29 and 30 March, 6 samples were sent to the UVRI and tested negative for all Ebola virus disease, Marburg virus disease, Crimean-Congo haemorrhagic fever, Rift Valley fever by polymerase chain reaction (PCR). On 8 April, Yellow Fever was confirmed on three samples by PCR, two blood samples tested positive for salmonella non-typhi and one tested positive for malaria. On 21 April, at least four samples were re-confirmed positive by PCR at CDC Fort Collins (WHO Collaborative Center for Yellow Fever).
From 26 March to 18 April, 30 cumulative suspected cases, including 7 deaths, were reported from Masaka, Rukungiri, Ntungamo, Bukumansimbi, Kalungu, Lyantonde, and Rakai. Of these, 6 cases and 2 deaths were confirmed in Masaka district (5 cases), and Rukungiri district (1 case). The mean age of the cases is 23 years old. The majority of cases are male. The cases do not have any history of travel outside of Uganda.
Public health response
The Ministry of Health of Uganda, with the support of WHO, Centers for Disease Control, Médecins Sans Frontières and other partners are supporting the response to the outbreak. WHO AFRO shared relevant guiding documents with the country for conducting risk assessment, vector control and outbreak management. The district task force which coordinates the response at district level developed a response plan and meets regularly. A multidisciplinary investigation team (physicians, laboratory experts, communication specialists, an epidemiologist and an entomologist) was sent to the affected district to conduct in-depth investigations and provide technical support to the District Task Force. Active surveillance has been enhanced through the activation of the alert desk and provision of alert free lines to the public. Case management, social mobilization, reactive vaccination and a rapid YF risk assessment are ongoing. A YF management centre was established in Masaka and Yellow Fever vaccine has already been requested from the International Coordinating Group on Vaccine Provision for reactive vaccination.WHO risk assessment
The current outbreak in Uganda is occurring in the context of international export of YF cases from Angola to China, the Democratic Republic of the Congo, and Kenya. Uganda is situated in the “Yellow Fever belt” of Africa and is considered a country at risk of Yellow Fever virus transmission. Last outbreak of Yellow Fever was reported in December 2011. The affected districts are in south-western Uganda close to Democratic Republic of Congo, Rwanda and Tanzania. As the borders are porous with substantial cross border social and economic activities, further transmission cannot be excluded. WHO continues to monitor the epidemiological situation and conduct risk assessment based on the latest available information.Yellow fever – Democratic Republic of the Congo
On 22 March 2016, the National IHR Focal Point of the Democratic Republic of Congo (DRC) notified WHO of cases of Yellow Fever (YF) in connection with the outbreak currently occurring in Angola (see DON posted 13 April 2016).
From early January to 22 March, a total of 453 suspect cases of YF, including 45 deaths were reported by the national surveillance system.
Further investigations identified 41 cases potentially related to the Angola outbreak. These cases were confirmed by laboratory testing at the Institute National of Biomedical Research (INRB) in Kinshasa. Of these 41 cases, 16 have also been confirmed by the regional reference laboratory, Pasteur Institute (IP) in Dakar: 13 of the cases were detected in Kongo Central province (formerly Bas-Congo) and 3 cases reported from Kinshasa. Kongo Central province shares a long, porous border with Angola.
Laboratory testing for the other 25 probable cases is pending at IP Dakar. Of these pending cases, two are identified as probable cases of autochthonous transmission – one from Kinshasa, and one from Matadi (in Kongo Central province). Investigations are ongoing and complementary testing at IP Dakar is pending.
An investigation team with the support of a virologist from IP Cameroon conducted an outbreak investigation from 7-18 April to assess the presence of local transmission and the risk of amplification. The conducted entomological survey found a high density of Aedes aegypti mosquito larvae, samples of which have also been sent to IP Dakar for infectivity investigation. High entomological density indicates that the risk for amplification of disease is very high.
The Government officially declared an outbreak of Yellow Fever on 23 April 2016.
Key response activities include:
With support from WHO and partners, the country has developed a contingency plan to improve the country's preparedness for a possible response to a larger YF outbreak. The plan is to vaccinate 8 health zones with at least 2 districts in Kinshasa and the six districts of Kongo Central where laboratory confirmed cases were identified (a total of nearly 2 million persons). If local transmission is laboratory confirmed, then other districts would be targeted accordingly.
YF was introduced in the routine EPI in Kinshasa in 2003. According to available data, most of the Capital’s districts (71%) had insufficient YF vaccination coverage (<80%) between 2012-2014. The country, with the support of WHO and partners, needs to implement adequate control measures especially reactive vaccination campaigns in order to avoid geographical spread within the country and to bordering countries.
Given the large Angolan community in Kinshasa, the presence and the activity of the vector Aedes spp, the potential establishment of local cycle of transmission in DRC in general and in Kinshasa in particular (the population of Kinshasa Province is estimated at 12.9 million) are of real concern and need to be monitored with extreme attention.
The last investigation highlighted the high risk of local transmission; made evident by factors such as high entomologic indices, movement of people between Angola and DRC, and the regular importation of viraemic cases from Angola.
The report of Yellow Fever infection in travellers and workers returning from Angola also highlights the risk of international spread of the disease.
From early January to 22 March, a total of 453 suspect cases of YF, including 45 deaths were reported by the national surveillance system.
Further investigations identified 41 cases potentially related to the Angola outbreak. These cases were confirmed by laboratory testing at the Institute National of Biomedical Research (INRB) in Kinshasa. Of these 41 cases, 16 have also been confirmed by the regional reference laboratory, Pasteur Institute (IP) in Dakar: 13 of the cases were detected in Kongo Central province (formerly Bas-Congo) and 3 cases reported from Kinshasa. Kongo Central province shares a long, porous border with Angola.
Laboratory testing for the other 25 probable cases is pending at IP Dakar. Of these pending cases, two are identified as probable cases of autochthonous transmission – one from Kinshasa, and one from Matadi (in Kongo Central province). Investigations are ongoing and complementary testing at IP Dakar is pending.
An investigation team with the support of a virologist from IP Cameroon conducted an outbreak investigation from 7-18 April to assess the presence of local transmission and the risk of amplification. The conducted entomological survey found a high density of Aedes aegypti mosquito larvae, samples of which have also been sent to IP Dakar for infectivity investigation. High entomological density indicates that the risk for amplification of disease is very high.
The Government officially declared an outbreak of Yellow Fever on 23 April 2016.
Public health response
The Ministry of Health of DRC has activated the National Committee for outbreak management to respond to this event.Key response activities include:
- establishment of coordination mechanisms
- social mobilization and community engagement
- case management
- strengthening surveillance through the training of health workers
- dissemination of case definitions
- screening and sanitary controls at Points of Entry and screening of refugees’ vaccination status
- reactive vector control activities and sensitization of all health facilities (public, private, and traditional practitioners)
- vaccination of all individuals travelling to Angola.
With support from WHO and partners, the country has developed a contingency plan to improve the country's preparedness for a possible response to a larger YF outbreak. The plan is to vaccinate 8 health zones with at least 2 districts in Kinshasa and the six districts of Kongo Central where laboratory confirmed cases were identified (a total of nearly 2 million persons). If local transmission is laboratory confirmed, then other districts would be targeted accordingly.
WHO risk assessment
The situation in DRC is concerning and must be monitored with the highest vigilance. DRC is located in a geographical area known to be YF endemic and autochthonous cases are regularly reported in the whole country. Since January 2016, autochthonous suspected cases have been recorded in the provinces of Bas-Uele, Equateur, Kasai central and Tshuapa. The last outbreaks were reported in Kasai n Oriental in 2013 and in Province Oriental and Katanga in 2014.YF was introduced in the routine EPI in Kinshasa in 2003. According to available data, most of the Capital’s districts (71%) had insufficient YF vaccination coverage (<80%) between 2012-2014. The country, with the support of WHO and partners, needs to implement adequate control measures especially reactive vaccination campaigns in order to avoid geographical spread within the country and to bordering countries.
Given the large Angolan community in Kinshasa, the presence and the activity of the vector Aedes spp, the potential establishment of local cycle of transmission in DRC in general and in Kinshasa in particular (the population of Kinshasa Province is estimated at 12.9 million) are of real concern and need to be monitored with extreme attention.
The last investigation highlighted the high risk of local transmission; made evident by factors such as high entomologic indices, movement of people between Angola and DRC, and the regular importation of viraemic cases from Angola.
The report of Yellow Fever infection in travellers and workers returning from Angola also highlights the risk of international spread of the disease.
WHO advice
There is urgent need to strengthen the Yellow Fever vaccination requirements for travellers in accordance to IHR (2005). Yellow Fever can easily be prevented by immunization provided vaccination is administered at least 10 days before travel. WHO urges Member States especially those where the establishment of a local cycle of transmission is possible (i.e. where the vector Aedes aegypti mosquitoes is present) to ensure that travellers to or from countries with current Yellow Fever transmission are vaccinated against Yellow Fever.
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